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Last publication Press

Carthera receives Orphan Drug Designation (ODD) from US and EU authorities for carboplatin in malignant glioma

14 may 2024 - Orphan designation shows recognition of enhanced therapeutic potential of carboplatin when used with Carthera’s SonoCloud® technology.

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Press

Carthera partners with Agenus and Northwestern University for phase 2a trial combining SonoCloud-9® with checkpoint inhibitors to treat glioblastoma

9 april 2024 - World-first trial could change standard of care for unmethylated glioblastoma patients.

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Press

Positive results from phase I/II clinical trial of SonoCloud-9® in treatment of glioblastoma published in Nature Communications

5 march 2024 - Results demonstrate safety and potential efficacy of SonoCloud-9® in treating recurrent glioblastoma.

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Press

Carthera enrolls first patient in pivotal trial of SonoCloud-9® device for treatment of recurrent glioblastoma

February 5, 2024 - Registrational study aims to enroll 560 US and EU patients over next two years, with view to obtaining marketing authorization.

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Press

Series B round reaches €42M

December 11, 2023 - Carthera announces an additional €4.5M in funding to complement its Series B financing round, bringing the total raised to €42M ($45M).

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Press

Carthera signs strategic collaboration with Accord Healthcare

November 6, 2023 - Carthera announces the signing of a strategic collaboration with Accord Healthcare Limited, a leading pharmaceutical company, for the supply of carboplatin.

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Press

Carthera appoints Dr. Oern Stuge as chairman of board of directors

September 18, 2023 – Medical device industry executive with 30+ years expertise brings wealth of experience in product development and commercial launches to support Carthera’s future growth.

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Press

Carthera closes €37.5M Series B funding round

June 27, 2023 - New funds will help launch pivotal multicenter trial in patients with recurrent glioblastoma and advance clinical pipeline.

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Press

Promising results from SonoCloud-9 clinical trial in combination with nab-paclitaxel have been published in Lancet Oncology

May 3, 2023 - Four-to six-fold increase in drug concentrations measured in human brain after blood-brain barrier opening with SonoCloud-9 System

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Press

Carthera announces positive outcome of End-of-Phase 2 meeting with FDA for SonoCloud-9 system for treatment of recurrent glioblastoma

March 13, 2023 - Carthera and FDA aligned on key aspects of proposed pivotal trial design.

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    logo-carthera Scientific Publications

    Last publication Scientific publication

    Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas

    Nature Communications - June 2024

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    Scientific publication

    Paclitaxel and Carboplatin in Combination with Low-Intensity Pulsed Ultrasound for Glioblastoma

    Clinical Cancer Research - April 2024

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    Scientific publication

    Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

    Nature Communications - February 2024

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    Scientific publication

    Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase I clinical trial

    Lancet Oncology - May 2023

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    Scientific publication

    Evaluating drug delivery enhancement following ultrasound treatment

    Lancet Oncology - May 2023

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    Scientific publication

    Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas

    Advances in Oncology - May 2023

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    Scientific publication

    Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials

    Cancers - January 2023

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    Scientific publication

    Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model

    Pharmaceutics - January 2023

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    Scientific publication

    Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer's disease

    Alzheimer’s Research & Therapy - March 2022

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    Scientific publication

    Opening of the Blood-Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

    Clinical Cancer Research - August 2021

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