At CarThera, we have by-passed the problem of the skull bone by taking advantage of the necessary clinical step of tumor biopsy before any treatment. No clinician worldwide can envision beginning a chemotherapy or radiotherapy treatment without a previous histological diagnosis. We have designed and developed a probe that is able to emit high intensity ultrasound that can be inserted within the tumor as a biopsy needle under local anesthesia. The probe performs not only the necessary biopsy but also the ultrasound treatment of the tumor in the same procedure under real-time MRI control.
Ultrasound emitted at a lower intensity is also able to interact with the biological tissue without destroying it. Using low-intensity pulsed ultrasound, it is possible to temporarily make the blood vessels more porous to drugs. In the brain, the vessels are particularly tight (Blood-Brain Barrier or BBB), preventing the penetration of chemotherapy in the brain and significantly reducing its effectiveness.
At CarThera®, we have developed an implantable medical device containing a low intensity ultrasound transducer, the SonoCloud®, which is able to temporarily open the blood-brain barrier. At each chemotherapy session, the BBB can be opened in order to optimize the penetration of the chemotherapy in the brain while reducing the side effects in the rest of the body.