Therapeutic ultrasound for brain disorders


Given the neurosurgical specialty of Professor Carpentier, the SonoProbe was designed for the treatment of brain disorders including brain tumors, epilepsy, metastases, meningiomas, … whose annual incidence in Europe and the USA exceeds 400,000 patients. These are indications that will be developed in future clinical studies.

In addition, the SonoProbe is adaptable for the treatment of diseases in organs such as the lung or in organs located behind bone structures such as the liver.



The primary objective of the SonoCloud® implant is to increase the intracerebral bioavailability of chemotherapy. It is therefore perfectly suited to the treatment of primary brain tumors (gliomas, glioblastomas, astrocytomas, …) as well as secondary brain tumors (metastases) … thus, the annual incidence in Europe and the USA exceeds 250,000 patients. The clinical study currently underway is for patients with glioblastoma.

More generally, the SonoCloud® implant allows for the passage of many substances that are currently not able to enter the brain because of the blood-brain barrier. It can therefore be a potential tool for the treatment of neurodegenerative diseases such as Alzheimer’s Disease.

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  • News CarThera

    CarThera secures €5.7 million in funding for its DOME project

    October 12, 2016 – CarThera has received a grant of €5.7 million ($6.4m) for its DOME project. The funding was awarded under the call for proposals ‘Structuring R&D Projects for Competitiveness’ from France’s ‘Investments for the Future Program’, led by the General Investment Commission and run by Bpifrance.

    The grant will finance our SonoCloud Phase 2b/3 study in glioblastoma that will involve around 200 patients at centers in Europe and the United States. It will also fund a number of exploratory studies, including one on Alzheimer’s disease, building on the findings from the Phase 1/2a study that paved the way for a broader array of clinical indications.

    A world first published in Science Translational Medicine

    SonoCloud® uses ultrasound to achieve permeability of blood vessels in human brain, allowing increased penetration of therapeutic molecules

    Scientific paper published on June 15th 2016 in Science Translational Medicine supports concept of intracranial ultrasound implant developed by CarThera
    Research teams from AP-HP hospitals, UPMC University, INSERM laboratories and the ICM incubator performed this breakthrough on brain tumors, paving the way for broader applications in neurological disorders

    The Biovision 2016 Investor Conference selection committee special award went to CarThera!

    The Investor Conference of Biovision is a unique opportunity for selected startups (28 over 120 candidates) to pitch in front of a jury of 15 of the major European VC.

    Biovision, The World Life Sciences Forum, brings together international decision makers from the academic, private, policy-making and civil society sectors. It took place 13–14 April 2016 in Lyon, France.