SonoCloud

Low Intensity Contact Ultrasound Implant 

Clinical Developments

A phase 1/2a clinical trial is currently in progress to study the transient opening of the blood-brain barrier (BBB) using the SonoCloud® during chemotherapy administration in patients with recurrent glioblastoma.

This study is a prospective multidisciplinary single-arm mono-center study that is being performed by the departments of Neurosurgery and Neuro-Oncology at the Hospital Pitie Salpetriere. The study sponsor is l’Assistance Publique des Hôpitaux de Paris.

The study addresses patients with gliobastoma that have experienced recurrence after initial standard of care treatments and who are eligible for carboplatin chemotherapy. Patient inclusion is discussed on a case by case basis during multidisciplinary department meetings.

The goal of this Phase 1/2a clinical study is to temporarily disrupt the BBB using low intensity pulsed ultrasound during chemotherapy sessions with carboplatin, with the goal of increasing the concentration of chemotherapeutic agent in the brain tissue. Additional information is available on the site clinicaltrials.gov:

http://clinicaltrials.gov/ct2/show/NCT02253212?term=sonocloudrank=1

 

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  • News CarThera

    03.07.2017
    CarThera presented data from phase 1/2a study at 2017 ASCO annual meeting

    June 2017 – Dr. Ahmed Idbaih, AP-HP principal investigator of the Phase 1/2a clinical trial (NCT02253212) on ultrasound induced Blood-Brain Barrier opening revealed preliminary safety and efficacy data at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

    The clinical data from the trial involving 21 patients with recurrent glioblastoma, who have all been treated with SonoCloud® low-intensity pulsed ultrasound in a total of 65 sessions, have been shared with more than 30,000 oncology professionals from around the world.

    14.10.2016
    CarThera secures €5.7 million in funding for its DOME project

    October 12, 2016 – CarThera has received a grant of €5.7 million ($6.4m) for its DOME project. The funding was awarded under the call for proposals ‘Structuring R&D Projects for Competitiveness’ from France’s ‘Investments for the Future Program’, led by the General Investment Commission and run by Bpifrance.

    The grant will finance our SonoCloud Phase 2b/3 study in glioblastoma that will involve around 200 patients at centers in Europe and the United States. It will also fund a number of exploratory studies, including one on Alzheimer’s disease, building on the findings from the Phase 1/2a study that paved the way for a broader array of clinical indications.

    15.06.2016
    A world first published in Science Translational Medicine

    SonoCloud® uses ultrasound to achieve permeability of blood vessels in human brain, allowing increased penetration of therapeutic molecules

    Scientific paper published on June 15th 2016 in Science Translational Medicine supports concept of intracranial ultrasound implant developed by CarThera
     
    Research teams from AP-HP hospitals, UPMC University, INSERM laboratories and the ICM incubator performed this breakthrough on brain tumors, paving the way for broader applications in neurological disorders